J Med Assoc Thai 1997; 80 (11):738

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Bone Density in Women Receiving Norplant* Implants for Contraception
Intaraprasert S Mail, Taneepanichskul S , Theppisai U , Chaturachinda K

The aim of this study was to determine whether long-term Norplant® uses is associated
with changes in bone density. The study group consisted of forty one healthy women aged 19-42
years who had used Norplant® for 31.1 ± 11.2 months with a minimum period of 12 months. Fifty
current IUD users constituted the control group. The bone density was measured by dual energy
X-ray absorptiometry (DEXA) at the non dominant distal and ultradistal forearm. Serum estradiol
was measured by rnicroparticle enzyme immunoassay technique. Age, parity, income, weight,
height and body mass index (BMI) of both groups were no differences. Our analysis did not find
any differences in bone mineral density of distal forearm and ultradistal forearm between Norplant
® and IUD users (95% CI -0.01, -0.03 and -0.02, 0.02 respectively). Serum estradiol was
not different in the two groups (95% CI -24.9,110). This study revealed that the Norplant®
implants do not have any adverse effect on bone mineral density.

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