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Original ArticleOpen Access
Effect of Different Oral Anticoagulant Intensities on Prothrombin Fragment 1+2 in Thai Patients with Mechanical Heart Valve Prostheses
Tientadakul P 
,
Opartkiattikul N ,
Sangtawesin W ,
Sakiyalak P
,
Opartkiattikul N ,
Sangtawesin W ,
Sakiyalak P The minimal intensity of oral anticoagulant required for antithrombotic protection in
patients with a mechanical heart valve is still debatable, and that of the Westerner may not be
directly applied to Thai patients. Our preliminary clinical review suggested that International Normalized
Ratio (INR) 2-3 might be enough but it needs further supporting evidence. Therefore, we
studied the effect of different anticoagulant intensities, expressed as INR, on the in vivo coagulation
activation by measuring prothrombin fragment 1 +2 (F1 +2) in 116 patients with mechanical
heart valve replacements. The patients had received warfarin for not less than one month with different
intensities. The mean ± S.D. of F1+2 level in 30 normal controls was 0.7±0.17 nmol/L.
After excluding two outliers, the maximum linear correlation between INR and Fl +2 was -0.658
(p
patients with a mechanical heart valve is still debatable, and that of the Westerner may not be
directly applied to Thai patients. Our preliminary clinical review suggested that International Normalized
Ratio (INR) 2-3 might be enough but it needs further supporting evidence. Therefore, we
studied the effect of different anticoagulant intensities, expressed as INR, on the in vivo coagulation
activation by measuring prothrombin fragment 1 +2 (F1 +2) in 116 patients with mechanical
heart valve replacements. The patients had received warfarin for not less than one month with different
intensities. The mean ± S.D. of F1+2 level in 30 normal controls was 0.7±0.17 nmol/L.
After excluding two outliers, the maximum linear correlation between INR and Fl +2 was -0.658
(p
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