J Med Assoc Thai 1997; 80 (3):147

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Serum Estradiol and Gonadotropins Level in Postmenopausal Women with or without Hormone Replacement
Limpaphayom K Mail, Taechakraichana N , C

Serum follicle stimulating hormone (FSH), luteinizing hormone (LH) and estradiol (E,)
was measured in 49 menopausal women, to assess the changing serum level in women with or
without hormone replacement. Women in the study group (N=25) received estrogen with or without
progestin. The control group (N=24) did not receive any hormone regimen. Serum hormone
measurement was done at 0, 6 and 12 month, using time-resolved fluoroimmunoassay method.
The results revealed no significant change of FSH, LH and E2 at 0, 6 and 12 month in the control
group. (FSH at 0, 6, 12 month : 55.14±22.82, 63.90±24.54, 72.81±29.58 lUlL, P=0.09; LH at
0, 6, 12 month : 35.54±19.86, 33.02±16.30, 32.33±17.37 lUlL, P=0.83; E2 at 0, 6, 12 month : 49.28±
48.54, 37 .29±39.93, 25.63±23.58 pmol/L, P=0.17). However, in the study group, FSH
and LH significantly decreased but E2 significantly increased at 6 and 12 months. (FSH at 0, 6,
12 month : 59.33±22.30, 27.23±16.31, 29.74±19.45 lUlL, P

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