J Med Assoc Thai 1997; 80 (3):153

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Osteosarcoma : A Study of 130 Cases
Pochanugool L Mail, Sangthawan D , Subhadharaphandou T , Dangprasert S , Hathirat P , Sirikulchayanonta V , Ratanatharathom V , Tannanonta C , Onsanit S , Yuktanonda P

Multidisciplinary treatment of osteosarcoma in the Faculty of Medicine Ramathibodi
Hospital, Mahidol University, using preoperative intraarterial and postoperative chemotherapy,
with or without local irradiation, combined with surgery and prophylactic lung irradiation provided
an excellent 5 years' survival of 55 per cent, the same rate as the 9 years' survival. The survival
was stable after 4.4 years. The patients with local irradiation had more tumor destruction
apparent on the surgical specimen. The administration of prophylactic whole lung irradiation provided
an outcome without any undesirable complication. Sixteen per cent of the cases with PLI
developed lung metastasis compared to 48 per cent without PLI. The most important prognostic
factor was low level of serum lactic acid dehydrogenase. The unanswered question is what is the
optimal treatment for osteosarcoma?

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