J Med Assoc Thai 1997; 80 (3):202

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Antitriiodothyronine Antibody in Patient with Hashimoto's Thyroiditis
Plengvidhya N Mail, Sunthornthepvarakul T , Vannasaeng S

We described a 44-year-old female patient with a history of goiter for 2 months. Physical
examination revealed a diffusely enlarged thyroid gland weighing 40 g firm to hard in consistency.
She was clinically euthyroid and had neither ophthalmopathy nor dermopathy. Serum thyroid
hormone levels revealed total T4 (RIA) of 4.8 flg/dL (normal, 4-11 flg/dL), total T 3 (RIA) of
above 600 ng/dL (70-175 ng/dL), and TSH (IRMA) of 54 mUlL (0.3-6 mUlL). Antithyroglobulin
and antiperoxidase antibody titers were 1:5,120 and 1:409,260, respectively. Because of the discrepancy
between the patient's clinical status and laboratory values, assay for thyroid hormone
autoantibodies (THAA) was done and subsequently demonstrated antitriiodothyronine antibody
with percentage of precipitation by polyethylene of 98.4 per cent (normal range, 3.06±8.58%).
In conclusion, THAA should be suspected in patients whose clinical status is incoherent with the
thyroid function test.

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