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Original ArticleOpen Access
Hepatic Peripheral T -cell Lymphoma : A Spectrum of Liver Pathology and Clinical Correlation
Mitarnun W 
,
Kietthubthew S ,
Suwiwat S
,
Kietthubthew S ,
Suwiwat S Thirty-two patients with fever of unknown origin, weight loss, anemia, elevated serum levels
of alkaline phosphatase and/or lactate dehydrogenase were evaluated. Histopathologic findings of
the liver showed T-cell infiltration in the hepatic sinusoids and portal tracts. The cellular morphology
varied from mature lymphocyte to malignant lymphoid cells. We divided the cases into four
groups on the basis of cellular atypia. Group A and group B showed mature lymphoid cell infiltration,
however, only group B had multiple large areas of hepatocellular necrosis. Group C showed atypical
lymphoid cell infiltration. In group D, definite malignant lymphoid cell infiltrates were demonstrated.
Groups B, C, and D patients had a very poor prognosis. All of them died despite chemotherapy.
Group A patients had a better prognosis. Those who had chemotherapy achieved a complete
remission. Progression to a higher group occurred in two of six patients with group B lesions and one
of seven patients with group C lesions. The EBV-RNA genomes were found increasingly in the
higher groups. This study supports the concept that these groups of disease represent a spectrum
of peripheral T-cell proliferations.
of alkaline phosphatase and/or lactate dehydrogenase were evaluated. Histopathologic findings of
the liver showed T-cell infiltration in the hepatic sinusoids and portal tracts. The cellular morphology
varied from mature lymphocyte to malignant lymphoid cells. We divided the cases into four
groups on the basis of cellular atypia. Group A and group B showed mature lymphoid cell infiltration,
however, only group B had multiple large areas of hepatocellular necrosis. Group C showed atypical
lymphoid cell infiltration. In group D, definite malignant lymphoid cell infiltrates were demonstrated.
Groups B, C, and D patients had a very poor prognosis. All of them died despite chemotherapy.
Group A patients had a better prognosis. Those who had chemotherapy achieved a complete
remission. Progression to a higher group occurred in two of six patients with group B lesions and one
of seven patients with group C lesions. The EBV-RNA genomes were found increasingly in the
higher groups. This study supports the concept that these groups of disease represent a spectrum
of peripheral T-cell proliferations.
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