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Original ArticleOpen Access
Efficacy of Using Basal Plasma Adrenocorticotropic Hormone-radioimmunoassay ACTH-RIA) Level in the Identification of the Cause of Cushing's Syndrome
Sriussadaporn S 
,
Ploybutr S ,
Peerapatdit T ,
Nitiyanant W ,
Vannasaeng S ,
Vichayanrat A
,
Ploybutr S ,
Peerapatdit T ,
Nitiyanant W ,
Vannasaeng S ,
Vichayanrat A Basal (8.00 a.m.) plasma ACTH-radioimmunoassay (ACTH-RIA) levels were studied in
32 cases of endogenous Cushing's syndrome (17 Cushing's disease, 13 adrenocortical tumors,
and 2 ectopic ACTH syndrome) and 11 normal volunteers. There were overlaps in the ranges of
plasma ACTH-RIA levels among patients with Cushing's disease, adrenocortical tumors, and normal
volunteers but not ectopic ACTH syndrome. By using different plasma ACTH-RIA levels as
cut-off points in differentiating ACTH-dependent from ACTH-independent Cushing's syndrome,
the level of 30 pg/ml had the highest diagnostic efficacy with a 94.7 per cent sensitivity, a 84.6 per
cent specificity and a 90.6 per cent diagnostic accuracy.
32 cases of endogenous Cushing's syndrome (17 Cushing's disease, 13 adrenocortical tumors,
and 2 ectopic ACTH syndrome) and 11 normal volunteers. There were overlaps in the ranges of
plasma ACTH-RIA levels among patients with Cushing's disease, adrenocortical tumors, and normal
volunteers but not ectopic ACTH syndrome. By using different plasma ACTH-RIA levels as
cut-off points in differentiating ACTH-dependent from ACTH-independent Cushing's syndrome,
the level of 30 pg/ml had the highest diagnostic efficacy with a 94.7 per cent sensitivity, a 84.6 per
cent specificity and a 90.6 per cent diagnostic accuracy.
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