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Original ArticleOpen Access
Termination of Second-Trimester Pregnancy with Intracervicovaginal Misoprostol
Srisomboon J 
,
Tongsong T ,
Pongpisuttinun S
,
Tongsong T ,
Pongpisuttinun S To evaluate the efficacy and side effects of intracervicovaginal misoprostol in termination
of second-trimester pregnancy in women with live fetuses. A total of 50 pregnant women between
14 and 27 week's gestation undergoing termination of pregnancy for medical, obstetrical and
genetic reasons were recruited to receive 200 ug misoprostol gel administered intracervicovaginally
every 12 hours.
The rates of sucessful abortions within 24 hours and 48 hours were 54 per cent and 92 per
cent respectively. The mean time from induction to abortion was 27.5 hours. The rate of complete
abortion, defined as the passage of the fetus and placenta without operative assistance was 80 per
cent. Side effects were fever (8% ), nausea and vomitting (6%) and diarrhea (2% ). Thirty one
patients (62%) required meperidine as analgesia. Two patients (4%) had postpartum hemorrhage.
Intracervicovaginal misoprostol is an effective, cheap, safe and relatively convenient
method for termination of second-trimester pregnancy with a live fetus.
of second-trimester pregnancy in women with live fetuses. A total of 50 pregnant women between
14 and 27 week's gestation undergoing termination of pregnancy for medical, obstetrical and
genetic reasons were recruited to receive 200 ug misoprostol gel administered intracervicovaginally
every 12 hours.
The rates of sucessful abortions within 24 hours and 48 hours were 54 per cent and 92 per
cent respectively. The mean time from induction to abortion was 27.5 hours. The rate of complete
abortion, defined as the passage of the fetus and placenta without operative assistance was 80 per
cent. Side effects were fever (8% ), nausea and vomitting (6%) and diarrhea (2% ). Thirty one
patients (62%) required meperidine as analgesia. Two patients (4%) had postpartum hemorrhage.
Intracervicovaginal misoprostol is an effective, cheap, safe and relatively convenient
method for termination of second-trimester pregnancy with a live fetus.
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