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Case ReportOpen Access
Bullous Pemphigoid in an Infant: A Case Report and Literature Review
Wisuthsarewong W 
,
Viravan S ,
Kulthanan K
,
Viravan S ,
Kulthanan K Bullous pemphigoid is an autoimmune bullous disease that is rare in children and infants.
It seems indistinguishable from the disease in adults although mucous membrane, palms and
soles involvement appear more commonly in childhood bullous pemphigoid. There is no association
with malignancy. The most reliable diagnostic criterias are the linear deposition of lgG and
C1 along the basement membrane zone and the presence of circulating IgG antibasement membrane
zone antibodies. The literature of bullous pemphigoid is reviewed and a case of a 7-monthold
girl with typical clinical manifestations and immunofluorescence studies is reported. She
responded very well to a high dose of systemic corticosteroid. The disease can be spontaneously
resolved and the prognosis for children is good in most cases.
It seems indistinguishable from the disease in adults although mucous membrane, palms and
soles involvement appear more commonly in childhood bullous pemphigoid. There is no association
with malignancy. The most reliable diagnostic criterias are the linear deposition of lgG and
C1 along the basement membrane zone and the presence of circulating IgG antibasement membrane
zone antibodies. The literature of bullous pemphigoid is reviewed and a case of a 7-monthold
girl with typical clinical manifestations and immunofluorescence studies is reported. She
responded very well to a high dose of systemic corticosteroid. The disease can be spontaneously
resolved and the prognosis for children is good in most cases.
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