J Med Assoc Thai 1997; 80 (5):338

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Progressive Cerebral Occlusive Disease After Hypothalamic Astrocytoma Radiation Therapy
Sinsawaiwong S Mail, Phanthumchinda K

An 18 year-old woman received radiation therapy for hypothalamic astrocytoma at the age
of 11 years. She developed progressive cerebral occlusive vascular disease with moyamoya vessels
formation in both carotid systems. Apart from diabetes mellitus, she had no other risk factors for
occlusive cerebrovascular disease. The site of occlusion was confined to the field of radiation and
the development of moyamoya vessels strongly suggestive of a radiation-induced cause. Radiation
therapy around the sella and parasellar region appears to be the most common risk factor for this
vasculopathy. Progressive irradiation-induced cerebral vasculopathy is due to accelerated atherosclerosis.

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