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Original ArticleOpen Access
Plasma Lipid Peroxide and Antioxidant Levels in Diabetic Patients
Kajanachumpol S 
,
Komindr S ,
Mahaisiriyodom A
,
Komindr S ,
Mahaisiriyodom A The present study was to investigate the levels of plasma lipid peroxide products including
malondialdehyde (MDA) and conjugated dienes (CD), and antioxidants including enzyme superoxide
dismutase, glutathione peroxidase, catalase, plasma vitamin E and vitamin C in diabetic
patients. Fifty-eight diabetic subjects; 16 males and 42 females, aged 30-75 years, were recruited.
Eighteen of them had diabetes and forty of them had diabetes with hyperlipidemia. Twenty-seven
healthy subjects, 8 males and 19 females, aged 30-75 years, were used as the control group.
The results showed that the concentrations of plasma MDA in diabetic patients with or
without hyperlipidemia tended to be increased when compared to the controls but there were no
significant differences. The CD values were increased significantly in both diabetic groups when
compared with control subjects. Significantly elevated levels of plasma MDA and CD were
found in diabetic patients with hypertriglyceridemia (> 150 mg% ). This increment did not change
the antioxidant status in both enzymes and vitamins except that the plasma vitamin E levels and
the ratios of tocopherol: cholesterol were increased significantly. An increase of lipid peroxide
in plasma may be one important factor in the development of vascular complication and atherosclerosis
seen in diabetic patients.
Oxygen
malondialdehyde (MDA) and conjugated dienes (CD), and antioxidants including enzyme superoxide
dismutase, glutathione peroxidase, catalase, plasma vitamin E and vitamin C in diabetic
patients. Fifty-eight diabetic subjects; 16 males and 42 females, aged 30-75 years, were recruited.
Eighteen of them had diabetes and forty of them had diabetes with hyperlipidemia. Twenty-seven
healthy subjects, 8 males and 19 females, aged 30-75 years, were used as the control group.
The results showed that the concentrations of plasma MDA in diabetic patients with or
without hyperlipidemia tended to be increased when compared to the controls but there were no
significant differences. The CD values were increased significantly in both diabetic groups when
compared with control subjects. Significantly elevated levels of plasma MDA and CD were
found in diabetic patients with hypertriglyceridemia (> 150 mg% ). This increment did not change
the antioxidant status in both enzymes and vitamins except that the plasma vitamin E levels and
the ratios of tocopherol: cholesterol were increased significantly. An increase of lipid peroxide
in plasma may be one important factor in the development of vascular complication and atherosclerosis
seen in diabetic patients.
Oxygen
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