J Med Assoc Thai 1997; 80 (7):440

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Azithromycin in Non-Gonococcal Urethritis
Charoenwatanachokchai A Mail, Chitwarakom A , Palanuvej T , Pakdeewong S , Kreaurat M

The efficacy and safety of a single 1 g oral dose of azithromycin was evaluated in 100
male patients with non-gonococcal urethritis (NGU). Enrolled were men with ≥ 5 polymorphonuclear
leukocytes (PMNL) I high power field (HPF) (x 1000 magnification) in a Gram-stained
smear of urethral discharge with or without symptoms and signs of NGU. Of the 66 evaluable
patients, Chlamydia trachomatis was isolated from 18 cases (27.3%) and Ureaplasma urealyticum
from 12 cases (18.2% ). After treatment, signs and symptoms disappeared from 59 cases (89.4% ).
Forty-four cases (66.7%) showed reduced PMNL/HPF. C. trachomatis was eradicated in 18 cases
(1 00%) and U. urealyticum in 12 cases (83.3% ). One patient complained of mild dizziness,
moderate nausea, and palpitations. Single 1 g oral dose of azithromycin appears to be effective
and safe for treating chlamydia!, non-chlamydial, and ureaplasmal NGU. In addition, its ease
of use encourages patient compliance.

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