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Case ReportOpen Access
Leiomyosarcoma with Osteoclast-Like Giant Cells of the Uterus: A Case Report and Literature Review
Sukpan K 
,
Khunamornpong S ,
Suprasert P ,
Siriaunkgul S
,
Khunamornpong S ,
Suprasert P ,
Siriaunkgul S The presence of osteoclast-like giant cells (OGC) has been reported as a rare and distinct feature in uterine
leiomyosarcoma. To present knowledge, 11 cases have been described in the English literature. The authors report an
additional example in a 35-year-old woman who presented with a pelvic mass. Pulmonary metastasis was detected by the
preoperative CT scan. The hysterectomy specimen revealed a 11.5 cm intramural mass with hemorrhagic and necrotic center.
The histologic examination revealed pleomorphic sarcoma with OGC. The neoplastic cells were immunoreative for smooth
muscle actin and desmin. Minor intermixing component of conventional leiomyosarcoma and leiomyoma were identified at
the periphery of the malignant component. The patient died of disease after 16 months of diagnosis. To our knowledge, this is
the youngest case of uterine leiomyosarcoma with OGC. Leiomyosarcoma with OGC has an aggressive clinical course. The
tumor may occur in young patient and may arise from pre-existing leiomyoma.
Keywords: Uterus, Leiomyosarcoma, Osteoclast-like giant cells, Leiomyoma
leiomyosarcoma. To present knowledge, 11 cases have been described in the English literature. The authors report an
additional example in a 35-year-old woman who presented with a pelvic mass. Pulmonary metastasis was detected by the
preoperative CT scan. The hysterectomy specimen revealed a 11.5 cm intramural mass with hemorrhagic and necrotic center.
The histologic examination revealed pleomorphic sarcoma with OGC. The neoplastic cells were immunoreative for smooth
muscle actin and desmin. Minor intermixing component of conventional leiomyosarcoma and leiomyoma were identified at
the periphery of the malignant component. The patient died of disease after 16 months of diagnosis. To our knowledge, this is
the youngest case of uterine leiomyosarcoma with OGC. Leiomyosarcoma with OGC has an aggressive clinical course. The
tumor may occur in young patient and may arise from pre-existing leiomyoma.
Keywords: Uterus, Leiomyosarcoma, Osteoclast-like giant cells, Leiomyoma
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