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Original ArticleOpen Access
Calcium and Phosphate Solubility Curves for Parenteral Nutrient Solutions Containing Vaminolacte Ladda
M 
,
Puetpaiboon A ,
Apiromrak B
,
Puetpaiboon A ,
Apiromrak B Calcium and phosphate incompatibility in the total parenteral nutrient (TPN) solutions
is a common problem especially in neonates. Their combinations in TPN admixture must be tested
before use. We here investigated the compatibility of calcium and phosphate in TPN solutions
containing a newborn amino acid product, Vaminolact®. The TPN test-solutions contained 10 per
cent dextrose, 1, 2, or 3 per cent Vaminolact®, 4 mmole/L of magnesium sulphate and various
combinations of calcium gluconate and dipotassium phosphate. Precipitations and crystallizations
were inspected visually and microscopically after 24 hours standing at room temperature. Solubility
curves were made by plotting the maximum concentrations of calcium and phosphate at
which both were still compatible in the solution. Such curves are extremely helpful for clinicians
and pharmacists to administer maximum calcium and phosphate dose for individual patient
requirement.
is a common problem especially in neonates. Their combinations in TPN admixture must be tested
before use. We here investigated the compatibility of calcium and phosphate in TPN solutions
containing a newborn amino acid product, Vaminolact®. The TPN test-solutions contained 10 per
cent dextrose, 1, 2, or 3 per cent Vaminolact®, 4 mmole/L of magnesium sulphate and various
combinations of calcium gluconate and dipotassium phosphate. Precipitations and crystallizations
were inspected visually and microscopically after 24 hours standing at room temperature. Solubility
curves were made by plotting the maximum concentrations of calcium and phosphate at
which both were still compatible in the solution. Such curves are extremely helpful for clinicians
and pharmacists to administer maximum calcium and phosphate dose for individual patient
requirement.
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