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Original ArticleOpen Access
DNA Typing of the HLA-A, -B and -C Genes : Possible MHC Class I Haplotypes in the Northeastern-Thais
Romphruk A 
,
Leelayuwat C ,
Barusrux S ,
Puapairoj C ,
Romphruk A ,
Urwijitaroon Y
,
Leelayuwat C ,
Barusrux S ,
Puapairoj C ,
Romphruk A ,
Urwijitaroon Y The phenotype and gene frequencies of HLA class I were studied in the Northeastern
Thai population. Blood samples were collected from 100 unrelated healthy northeastern-Thais.
HLA-A, -B and -Cw alleles were determined using the polymerase chain reaction- amplification
refractory mutation system (PCR-ARMS). 12 HLA-A, 20 HLA-B and 14 HLA-Cw alleles were
found. Linkage disequilibrium analysis indicated the existence of 7 HLA-A-B and 19 HLA-B-Cw
haplotypes. A*0207-Cw*Ol-B*4601 was the most common possible haplotype in this population.
These results provide regional basic information for further studies in anthropology, organ
transplantation and MHC disease associations in the northeastern-Thais.
Thai population. Blood samples were collected from 100 unrelated healthy northeastern-Thais.
HLA-A, -B and -Cw alleles were determined using the polymerase chain reaction- amplification
refractory mutation system (PCR-ARMS). 12 HLA-A, 20 HLA-B and 14 HLA-Cw alleles were
found. Linkage disequilibrium analysis indicated the existence of 7 HLA-A-B and 19 HLA-B-Cw
haplotypes. A*0207-Cw*Ol-B*4601 was the most common possible haplotype in this population.
These results provide regional basic information for further studies in anthropology, organ
transplantation and MHC disease associations in the northeastern-Thais.
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