Views: 1,439 | Downloads:
19
| Responses: 0
| XML | Respond to this article | Alert & updates | Request permissions | Email to a friend |
Original ArticleOpen Access
Panel Reactive Antibodies in Post-Kidney Transplantation
Mongkolsuk T 
,
Sumethkul V ,
Sujirachato K ,
Domrongkitchaiporn S ,
Junpong S ,
Chiewsilp P
,
Sumethkul V ,
Sujirachato K ,
Domrongkitchaiporn S ,
Junpong S ,
Chiewsilp P This study was aimed to evaluate the clinical relevance of the panel reactive antibodies
(PRA) post kidney transplantation (KT). A total number of 90 KT recipients consisted of 71 male
and 19 female patients. Thirty-two haploidentical and 3 HLA-identical pairs for living related KT
and 55 cadaveric KT with 3-6 mismatched antigens were il}Cluded in this study. The analysis
revealed that there were 2 out of 69 (2.89%) patients with no episode of rejection who had Pre-KT
PRA-T and or PRA-B > 80 per cent while they were 5.79 per cent and 23.19 per cent for Post-KT.
No patient in 21 cases with KT rejection had Pre-KT-PRA-T and -B > 80 per cent. There was significant
increase of antibodies in Post-KT rejections which were 28.57 per cent and 33.3 per cent
for Post-KT-PRA-T and -B respectively. None of 3 cases with graft failure (GF) from chronic
rejection had Pre-KT-PRA-T and -B >20 per cent and only one of them had Post-KT-PRA-T = 80
per cent. No donor specific HLA antibody was found among this group of patients. Although
antibody to donor HLA antigens was not observed in these patients, the increase of PRA-T and -B
in Post-KT may indicate the immunological reaction resulting in GF.
(PRA) post kidney transplantation (KT). A total number of 90 KT recipients consisted of 71 male
and 19 female patients. Thirty-two haploidentical and 3 HLA-identical pairs for living related KT
and 55 cadaveric KT with 3-6 mismatched antigens were il}Cluded in this study. The analysis
revealed that there were 2 out of 69 (2.89%) patients with no episode of rejection who had Pre-KT
PRA-T and or PRA-B > 80 per cent while they were 5.79 per cent and 23.19 per cent for Post-KT.
No patient in 21 cases with KT rejection had Pre-KT-PRA-T and -B > 80 per cent. There was significant
increase of antibodies in Post-KT rejections which were 28.57 per cent and 33.3 per cent
for Post-KT-PRA-T and -B respectively. None of 3 cases with graft failure (GF) from chronic
rejection had Pre-KT-PRA-T and -B >20 per cent and only one of them had Post-KT-PRA-T = 80
per cent. No donor specific HLA antibody was found among this group of patients. Although
antibody to donor HLA antigens was not observed in these patients, the increase of PRA-T and -B
in Post-KT may indicate the immunological reaction resulting in GF.
Download:
PDF