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Original ArticleOpen Access
Levels of Serum Interleukin-6 and Tumor Necrosis Factor in Postsplenectomized Thalassemic Patients
Chuncharunee S 
,
Archararit N ,
Hathirat P ,
Udomsubpayakul U ,
Atichartakam V
,
Archararit N ,
Hathirat P ,
Udomsubpayakul U ,
Atichartakam V Levels of serum interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) were studied
in 34 nonsplenectomized thalassemic patients (Thal/nonsplenec ), 43 postsplenectomized thalassemic
patients (Thal/postsplenec ), 13 splenectomized non-thalassemic patients (non Thall
postsplenec) and 18 normal control by enzyme linked immunosorbent assay method. Serum IL-6
concentration in Thal/postsplenec was significantly increased when compared with Thall
nonsplenec and normal volunteers (3.55±2.47 pg/ml vs 2.38±2.31 pg/ml, p=0.036 and 3.55±2.47
pg/ml vs 2.66±0.45 pg/ml, p=0.028, respectively). This study also demonstrated that TNF-α value
in Thal/postsplenec was drastically increased above normal control level (15.8±4.86 pg/ml vs
9.16±2.18 pg/ml, p=0.001) and the level was statistically significantly higher than that in Thai/
nonsplenec (15.5±4.86 pg/ml vs 9.96±5.19 pg/ml, p=0.001). There was a trend toward increasing
of cytokine levels in Thal/postsplenec with higher platelet count although no correlation was
observed. This study addresses the possible role of IL-6 and TNF-α in the pathogenesis of
reactive thrombocytosis in Thal/postsplenec.
in 34 nonsplenectomized thalassemic patients (Thal/nonsplenec ), 43 postsplenectomized thalassemic
patients (Thal/postsplenec ), 13 splenectomized non-thalassemic patients (non Thall
postsplenec) and 18 normal control by enzyme linked immunosorbent assay method. Serum IL-6
concentration in Thal/postsplenec was significantly increased when compared with Thall
nonsplenec and normal volunteers (3.55±2.47 pg/ml vs 2.38±2.31 pg/ml, p=0.036 and 3.55±2.47
pg/ml vs 2.66±0.45 pg/ml, p=0.028, respectively). This study also demonstrated that TNF-α value
in Thal/postsplenec was drastically increased above normal control level (15.8±4.86 pg/ml vs
9.16±2.18 pg/ml, p=0.001) and the level was statistically significantly higher than that in Thai/
nonsplenec (15.5±4.86 pg/ml vs 9.96±5.19 pg/ml, p=0.001). There was a trend toward increasing
of cytokine levels in Thal/postsplenec with higher platelet count although no correlation was
observed. This study addresses the possible role of IL-6 and TNF-α in the pathogenesis of
reactive thrombocytosis in Thal/postsplenec.
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