Views: 1,431 | Downloads:
18
| Responses: 0
| XML | Respond to this article | Alert & updates | Request permissions | Email to a friend |
Original ArticleOpen Access
A Comparison Between 25 Micrograms and 50 Micrograms of Intravaginal Misoprostol for Labor Induction
Srisomboon J 
,
Singchai S
,
Singchai S Our purpose was to compare the efficacy 2:5 µg and 50 ug dosage of intravaginal misoprostol
for labor induction in patients with an unfavorable cervix. Fifty pregnant women were
randomly assigned to receive either 25 µg (24 cases) or 50 µg (26 cases) of intravaginal misoprostol
every 6 hours. The mean interval from induction to vaginal delivery was significantly
shorter in the 50 µg group (13.8 ± 6.6 hours) when compared with the 25 µg group (20.9 ± 9.5
hours) (P = 004). The average number of misoprostol doses needed per patient was significantly
fewer in the 50 µg group (1.6 ± 0.7 versus 2.3 ± 1.2, P = 0.018). The frequencies of
uterine tachysystole were 4.2 per cent and 7.7 per cent in the 25 µg and 50 µg groups respectively
which did not significantly differ. Requirement for oxytocin infusion in the 25 µg group was significantly
more than in the 50 µg group (66.6 % versus 23.1 % respectively, P = 0.004 ). Analgesia
requirement, delivery method, and perinatal outcomes were comparable in both groups.
In summary, intravaginal application of 50 µg misoprostol at 6-hour interval is comparable in
safety but more effective for labor induction than the 25 µg dosage.
for labor induction in patients with an unfavorable cervix. Fifty pregnant women were
randomly assigned to receive either 25 µg (24 cases) or 50 µg (26 cases) of intravaginal misoprostol
every 6 hours. The mean interval from induction to vaginal delivery was significantly
shorter in the 50 µg group (13.8 ± 6.6 hours) when compared with the 25 µg group (20.9 ± 9.5
hours) (P = 004). The average number of misoprostol doses needed per patient was significantly
fewer in the 50 µg group (1.6 ± 0.7 versus 2.3 ± 1.2, P = 0.018). The frequencies of
uterine tachysystole were 4.2 per cent and 7.7 per cent in the 25 µg and 50 µg groups respectively
which did not significantly differ. Requirement for oxytocin infusion in the 25 µg group was significantly
more than in the 50 µg group (66.6 % versus 23.1 % respectively, P = 0.004 ). Analgesia
requirement, delivery method, and perinatal outcomes were comparable in both groups.
In summary, intravaginal application of 50 µg misoprostol at 6-hour interval is comparable in
safety but more effective for labor induction than the 25 µg dosage.
Download:
PDF