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Original ArticleOpen Access
Results of Rapid Two-stage Arterial Switch Operation in Patients with Transposition of the Great Arteries : One-year Postoperation
Laohaprasitipom D 
,
Nana A ,
Soongswang J ,
Sriyoscharti S ,
Pomvirawan S ,
Prakanrattana U ,
Watthanaprakamchai W ,
Kangkagate C
,
Nana A ,
Soongswang J ,
Sriyoscharti S ,
Pomvirawan S ,
Prakanrattana U ,
Watthanaprakamchai W ,
Kangkagate C The rapid two-stage arterial switch operation is an alternative therapy for patients with
simple transposition of the great arteries who present beyond the neonatal period and have
low left ventricular pressure. It provides normal ventricular function compared to the atrial
switch operation. Between July 1994 and February 1997, there were 13 such infants who had
rapid two- stage arterial switch operation performed at Siriraj Hospital. There was 1 late death
(11 months after the operation). All 12 survivors (mean age 22.4±5.7 months) were clinically
evaluated and had echocardiography performed at 14.8±4.9 months after the operation. All
were asymptomatic. Echocardiogram revealed a residual small atrial septal defect (1 case), small
ventricular septal defect (1 case), mild supravalvar neopulmonary stenosis (2 cases), bicuspid
neoaortic valve without stenosis (2 cases), dilated neoaortic sinus of Valsalva (6 cases, 50%)
and mild neoaortic insufficiency ( 11 cases, 91.7% ). The left ventricular function was hyperdynamic
after pulmonary artery banding and significantly decreased to normal level at the time
of study (shortening fraction of 43.8±10.7 vs 29.2±3.8%, respectively, p = 0.0005). The wall
thickness was significantly increased after pulmonary artery banding and decreased overtime
(0.48±0.08 vs 0.32±0.05 em, respectively, p < 0.0005). The left ventricular dimension was
significantly increased both after pulmonary artery banding and at the time of study (2.06±0.42
vs 3.32±0.30 em, respectively, p < 0.0005). The left ventricular mass was significantly
increased after pulmonary artery banding and at the time of study (21.79±7.79 vs 33.08±7.40
gfm2, respectively, p = 0.0005). The mortality and morbidity of rapid two-stage arterial switch
operation are low. However, long-term follow-up should be monitored.
simple transposition of the great arteries who present beyond the neonatal period and have
low left ventricular pressure. It provides normal ventricular function compared to the atrial
switch operation. Between July 1994 and February 1997, there were 13 such infants who had
rapid two- stage arterial switch operation performed at Siriraj Hospital. There was 1 late death
(11 months after the operation). All 12 survivors (mean age 22.4±5.7 months) were clinically
evaluated and had echocardiography performed at 14.8±4.9 months after the operation. All
were asymptomatic. Echocardiogram revealed a residual small atrial septal defect (1 case), small
ventricular septal defect (1 case), mild supravalvar neopulmonary stenosis (2 cases), bicuspid
neoaortic valve without stenosis (2 cases), dilated neoaortic sinus of Valsalva (6 cases, 50%)
and mild neoaortic insufficiency ( 11 cases, 91.7% ). The left ventricular function was hyperdynamic
after pulmonary artery banding and significantly decreased to normal level at the time
of study (shortening fraction of 43.8±10.7 vs 29.2±3.8%, respectively, p = 0.0005). The wall
thickness was significantly increased after pulmonary artery banding and decreased overtime
(0.48±0.08 vs 0.32±0.05 em, respectively, p < 0.0005). The left ventricular dimension was
significantly increased both after pulmonary artery banding and at the time of study (2.06±0.42
vs 3.32±0.30 em, respectively, p < 0.0005). The left ventricular mass was significantly
increased after pulmonary artery banding and at the time of study (21.79±7.79 vs 33.08±7.40
gfm2, respectively, p = 0.0005). The mortality and morbidity of rapid two-stage arterial switch
operation are low. However, long-term follow-up should be monitored.
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