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Original ArticleOpen Access
Gentamicin Pharmacokinetics in Thai Neonates: Recommendation for a Dosing Guideline
Kanthawatana S 
,
Uruwannakul K ,
Chotinarumon S
,
Uruwannakul K ,
Chotinarumon S A pharmacokinetic study of gentamicin was performed on 32 Thai neonates. After a
single intravenous infusion of gentamicin at 2.5 mg/kg body weight, blood samples were collected
at 0.5 and 12 hours. Serum gentamicin concentrations were determined with use of fluorescence
polarizing immunoassay. None of the neonates with < 28 weeks post conceptional age
(PCA), contrary to most of the more mature neonates, achieved the recommended therapeutic
peak concentrations. The volume of distribution (V d) and elimination half-life (T 1/2) of gentamicin
were found to reversely correlate with the PCA, with significantly larger V d and longer T l/2
values observed among the premature neonates. Our findings were similar the results previously
reported in Caucasians, and thus strongly indicated the necessity of gentamicin dosage adjustment
among Thai neonates according to their PCA. A gentamicin dosing guideline for Thai neonates has
been proposed, nonetheless, with higher doses and longer dosing intervals recommended among
premature neonates.
single intravenous infusion of gentamicin at 2.5 mg/kg body weight, blood samples were collected
at 0.5 and 12 hours. Serum gentamicin concentrations were determined with use of fluorescence
polarizing immunoassay. None of the neonates with < 28 weeks post conceptional age
(PCA), contrary to most of the more mature neonates, achieved the recommended therapeutic
peak concentrations. The volume of distribution (V d) and elimination half-life (T 1/2) of gentamicin
were found to reversely correlate with the PCA, with significantly larger V d and longer T l/2
values observed among the premature neonates. Our findings were similar the results previously
reported in Caucasians, and thus strongly indicated the necessity of gentamicin dosage adjustment
among Thai neonates according to their PCA. A gentamicin dosing guideline for Thai neonates has
been proposed, nonetheless, with higher doses and longer dosing intervals recommended among
premature neonates.
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