J Med Assoc Thai 1998; 81 (2):141

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Methotrexate Induced Pericarditis and Pericardial Effusion in Psoristic Patient
Palungwachira P Mail, Palungwachira P , Laohathai P

We describe a 62-year-old woman with Psoriasis who presented as Methotrexate - induced
pericarditis and pericardia! effusion. Aspiration of the pericardium was required and the patient
made a satisfactory recovery. At six - months follow-up, she remained well, psoriasis plaques
was controlled by topical crude coal tar and topical corticosteroid. These complications are
extremely rare, but have been described as isolated phenomena associated with methotrexate
therapy.

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