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Original ArticleOpen Access
A Randomized Clinical Trial Comparing the Efficacy of Ranitidine and Famotidine on lntragastric Acidity in Critically Dl Pediatric Patients
Aanpreung P 
,
Vanprapar N ,
Boonyachart C
,
Vanprapar N ,
Boonyachart C We examined the efficacy of intravenous ranitidine and famotidine on raising intragastric
pH in each of 10 critically ill pediatric patients. The severity of illness was assessed by
using the modified zinner index score. The study had 3 phases and each phase took 24 hours.
Intragastric pH was measured by continuous pH monitoring digitrapper for 72 hours. In phase I
and 3, the patients did not receive any H2 blockers. In phase 2, they were randomized to receive
intravenous ranitidine or famotidine. The majority of cases had intragastric pH < 4 in day I
(base line). Ranitidine and famotidine increased total time of intragastric pH ≥ 4 from the base line
during day 2, 38.2 ± 16.9 per cent and 60.3 ± 24.8 per cent respectively (P0.004), but there was no
statistical difference between the 2 medications in both Zinner index score I and score greater
than I group (P 0.08, 0.45). Three cases in the famotidine group had successful prophylaxis
with total time pH ≥ 4 more than 80 per cent. Famotidine appeared to have a trend toward increasing
intragastrie pH in critically ill pediatric patients.
pH in each of 10 critically ill pediatric patients. The severity of illness was assessed by
using the modified zinner index score. The study had 3 phases and each phase took 24 hours.
Intragastric pH was measured by continuous pH monitoring digitrapper for 72 hours. In phase I
and 3, the patients did not receive any H2 blockers. In phase 2, they were randomized to receive
intravenous ranitidine or famotidine. The majority of cases had intragastric pH < 4 in day I
(base line). Ranitidine and famotidine increased total time of intragastric pH ≥ 4 from the base line
during day 2, 38.2 ± 16.9 per cent and 60.3 ± 24.8 per cent respectively (P0.004), but there was no
statistical difference between the 2 medications in both Zinner index score I and score greater
than I group (P 0.08, 0.45). Three cases in the famotidine group had successful prophylaxis
with total time pH ≥ 4 more than 80 per cent. Famotidine appeared to have a trend toward increasing
intragastrie pH in critically ill pediatric patients.
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