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Original ArticleOpen Access
Nomogram of Nuchal Fold Thickness of Thai Fetuses Saknan Manotaya, M.D .. Somchai Tanawattanacharoen, M.D ..
Uerpairojkit B 
,
Tannirandorn Y ,
Charoenvidhya D
,
Tannirandorn Y ,
Charoenvidhya D The aim of the study was to establish normal values of nuchal fold thickness during 14-21
weeks of pregnancy. Three hundred Thai pregnant women before 12 weeks of gestation were
recruited. Gestational age was determined by last menstrual period and confirmed by crown-rump
length. Subjects with date-size discrepancy of more than 7 days were excluded from the study.
Nuchal fold thickness was measured twice, first during 14-17 weeks, and then during 18-21
weeks. Five hundred and nine measurements were obtained. Nomogram of nuchal fold thickness
was constructed. Mean values of nuchal fold thickness increased steadily from 2.59±0.77
millimeters (mm) at 14 weeks to 4.12±0.98 mm at 21 weeks. Average rate of increase were 0.22
mm per week. In conclusion, nuchal fold thickness increased with advancing gestational age
from 14 to 21 weeks of pregnancy. Different normal cut-off levels for each gestational week
may be more appropriate for screening of fetal Down syndrome in Thai pregnant women.
weeks of pregnancy. Three hundred Thai pregnant women before 12 weeks of gestation were
recruited. Gestational age was determined by last menstrual period and confirmed by crown-rump
length. Subjects with date-size discrepancy of more than 7 days were excluded from the study.
Nuchal fold thickness was measured twice, first during 14-17 weeks, and then during 18-21
weeks. Five hundred and nine measurements were obtained. Nomogram of nuchal fold thickness
was constructed. Mean values of nuchal fold thickness increased steadily from 2.59±0.77
millimeters (mm) at 14 weeks to 4.12±0.98 mm at 21 weeks. Average rate of increase were 0.22
mm per week. In conclusion, nuchal fold thickness increased with advancing gestational age
from 14 to 21 weeks of pregnancy. Different normal cut-off levels for each gestational week
may be more appropriate for screening of fetal Down syndrome in Thai pregnant women.
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