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Original ArticleOpen Access
The Incidence of K-ras Codon 12 Mutations in Cholangiocarcinoma Detected by Polymerase Chain Reaction Technique
Wattanasirichaigoon S 
,
Tasanaklzajom U ,
Jesadapataraku S
,
Tasanaklzajom U ,
Jesadapataraku S In the study, to analyse a K-ras oncogene mutated at codon 12 in 24 patients with cholangiocarcinomas,
four (16.67%) of them contained this point mutation. One of 4 was peripheral
and the others were hilar tumors. There was no significant relationship between mutation and
clinical features in terms of age, sex, endemic area, tumor location, tumor grading and pathological
features. In our study, the incidence of K-ras codon 12 mutation in Thai patients with
cholangiocarcinoma was lower than that found in British and Japanese patients. The discrepancy
of incidence and type of the mutations, in different races and environment probably
indicates that there is/are different etiologic mechanism(s) in the pathogenesis of cholangiocarcinoma.
four (16.67%) of them contained this point mutation. One of 4 was peripheral
and the others were hilar tumors. There was no significant relationship between mutation and
clinical features in terms of age, sex, endemic area, tumor location, tumor grading and pathological
features. In our study, the incidence of K-ras codon 12 mutation in Thai patients with
cholangiocarcinoma was lower than that found in British and Japanese patients. The discrepancy
of incidence and type of the mutations, in different races and environment probably
indicates that there is/are different etiologic mechanism(s) in the pathogenesis of cholangiocarcinoma.
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