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Original ArticleOpen Access
Metabolic and Immune Effects of Dietary Arginine, Glutamine and Omega-3 Fatty Acids Supplementation in Immunocompromised Patients
Sittapairochana C 
,
Le01mttana W ,
Bunnak A
,
Le01mttana W ,
Bunnak A To evaluate the nutritional, metabolic and immune effects of dietary arginine, glutamine
and omega-3 fatty acids (fish oil) supplementation in immunocompromised patients, we performed
a prospective study on the effect of immune formula administered to II severe trauma
patients (average ISS = 24), 10 burn patients (average % TBSA = 48) and 5 cancer patients. Daily
calorie and protein administration were based on the patient's severity (Stress factor with the
range of 35-50 kcal/kg/day and 1.5-2.5 g/kg/day, respectively) Starting with half concentration
liquid immune formula through nasogastric tube by continuous drip at 30 ml/h and increasing
to maximum level within 4 days. The additional energy and protein requirement will be given
either by parenteral or oral nutritional support. Various nutritional, metabolic, immunologic and
clinical parameters were observed on day 0 (baseline), day 3, 7, and 14. Analysis was performed
by paired student-t test. Initial mean serum albumin and transferrin showed mild (trauma) to
moderate (burn and cancer) degree of malnutrition. Significant improvement of nutritional
parameters was seen at day 7 and 14 in trauma and burn patients. Significant increase of total
lymphocyte count (day 7, P
and omega-3 fatty acids (fish oil) supplementation in immunocompromised patients, we performed
a prospective study on the effect of immune formula administered to II severe trauma
patients (average ISS = 24), 10 burn patients (average % TBSA = 48) and 5 cancer patients. Daily
calorie and protein administration were based on the patient's severity (Stress factor with the
range of 35-50 kcal/kg/day and 1.5-2.5 g/kg/day, respectively) Starting with half concentration
liquid immune formula through nasogastric tube by continuous drip at 30 ml/h and increasing
to maximum level within 4 days. The additional energy and protein requirement will be given
either by parenteral or oral nutritional support. Various nutritional, metabolic, immunologic and
clinical parameters were observed on day 0 (baseline), day 3, 7, and 14. Analysis was performed
by paired student-t test. Initial mean serum albumin and transferrin showed mild (trauma) to
moderate (burn and cancer) degree of malnutrition. Significant improvement of nutritional
parameters was seen at day 7 and 14 in trauma and burn patients. Significant increase of total
lymphocyte count (day 7, P
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