J Med Assoc Thai 1998; 81 (6):393

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Zopiclone in the Treatment of Insomnia: An Open Cliniflll TJtsl
Disayavanish C Mail, Srisurapanont M , Disayavanish P

The purpose of this study was to examine the efficacy and adverse effects of zopiclone
in Thai psychiatric patients. Thirty-two insomniac outpatients with a variety of diagnoses participated
in this study. Zopiclone at the dose of 7.5-15 mg was administered 15 minutes before
bedtime. The sleep-questionnaire items included: I) sleep induction; 2) duration of sleep; 3) number
of awakenings, 4) sleep quality; 5) dream incidence; and 6) condition in the morning. The mean
scores of each item were compared by using pair t-test. One week after treatment, significant
improvement was found in all items, except item 5. In comparison between sleep at I week and 3
weeks after treatment, further improvement was still found in the first three items. The adverse
effects found were bitter taste, drowsiness, and headache. In conclusion, zopiclone is an effective
hypnotic with few adverse effects.

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