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Original ArticleOpen Access
Comparison of Short Versus Long Duration of Ampicillin and Gentamicin for Radical Hysterectomy
Maleemonkol S 
,
Chareoniam V ,
sariyodom P ,
Chaiyapan S
,
Chareoniam V ,
sariyodom P ,
Chaiyapan S Prophylactic antibiotic therapy for radical hysterectomy is still controversial. Although
the efficacy of antibiotics have been demonstrated, there remains the question of duration of
administration. In this study, we retrospectively reviewed 95 patients who underwent radical
hysterectomy and pelvic lymphadenectomy for cervical cancer at our institute. The management
was uniform except for the duration of antibiotic administration. Group I (34 cases) had ampicillin
and gentamicin for 3 days while group II (61 cases) had the same regimen for 7 days. No
significant difference was found in terms of postoperative infection (2.9% in group I and 1.6%
in group IT) or febrile morbidity (32.4% versus 50.8% ). Other factors such as the patients' age,
body weight, preoperaive hemoglobin level, amount of blood loss and blood transfused, operative
time, duration of retroperitoneal drain and duration of suprapubic cystostomy. Only operative
time had a significant influence on febrile morbidity regardless of the duration of antibiotics
administered. In conclusion, the antibiotic administration gave a radical hysterectomy and pelvic
lymphadenectomy a very low incidence of postoperative infection. Longer duration of treatment
did not appear to lessen postoperative infection nor febrile morbidity. Shorter duration of
antibiotic administration needs further evaluation.
the efficacy of antibiotics have been demonstrated, there remains the question of duration of
administration. In this study, we retrospectively reviewed 95 patients who underwent radical
hysterectomy and pelvic lymphadenectomy for cervical cancer at our institute. The management
was uniform except for the duration of antibiotic administration. Group I (34 cases) had ampicillin
and gentamicin for 3 days while group II (61 cases) had the same regimen for 7 days. No
significant difference was found in terms of postoperative infection (2.9% in group I and 1.6%
in group IT) or febrile morbidity (32.4% versus 50.8% ). Other factors such as the patients' age,
body weight, preoperaive hemoglobin level, amount of blood loss and blood transfused, operative
time, duration of retroperitoneal drain and duration of suprapubic cystostomy. Only operative
time had a significant influence on febrile morbidity regardless of the duration of antibiotics
administered. In conclusion, the antibiotic administration gave a radical hysterectomy and pelvic
lymphadenectomy a very low incidence of postoperative infection. Longer duration of treatment
did not appear to lessen postoperative infection nor febrile morbidity. Shorter duration of
antibiotic administration needs further evaluation.
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