J Med Assoc Thai 1998; 81 (8):641

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Atypical Granular Cell Tumor of the Neurohypophysis: A Case Report with Review of the Literature
Shuangshoti S Mail, Chantra K , Navalitloha Y , Charoonwatanalaoha S , Shuangshoti S

A 76-year-old man had an atypical granular cell tumor of the neurohypophysis which
showed pleomorphic nuclei, mitotic figures, and spindle-shaped cells, extremely rare findings to
be encountered. Review of 45 patients with neurohypophyseal granular cell tumor revealed a
ratio of 1 : 2 between male and female with the peak occurrence (31%) in the fifth decade, and
with the mean age of 50 years. There were no patients below 20 years of age. The common
clinical presentations included visual disturbances and endocrinopathies relating to sex hormones.
Surgical removal was the treatment of choice. If it is possible, total extirpation should
be attempted. Because of uncertain cellular origin, the lesion should be descriptively diagnosed
as granular cell tumor although multiple terms have been proposed.

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