Views: 1,322 | Downloads:
24
| Responses: 0
| XML | Respond to this article | Alert & updates | Request permissions | Email to a friend |
Original ArticleOpen Access
Impediment of the Progressions of Microalbuminuria and Hyperlipidemia in Normotensive Type 2 Diabetes by Low-Dose Ramipril
Vongterapak S 
,
Dahlan W ,
Nakasatien S ,
Anuntakulnatee T ,
Suppanich M ,
Kittipoom W ,
Surasingchaidet C ,
Tamwiwat C ,
Tepkasetkul M ,
Bunnag P ,
Ongphiphadhanakul B ,
Rajatanavin R ,
Himathongkam T
,
Dahlan W ,
Nakasatien S ,
Anuntakulnatee T ,
Suppanich M ,
Kittipoom W ,
Surasingchaidet C ,
Tamwiwat C ,
Tepkasetkul M ,
Bunnag P ,
Ongphiphadhanakul B ,
Rajatanavin R ,
Himathongkam T In a randomized, double-blind, placebo-controlled study, we investigated in normotensive
type 2 diabetics with rnicroalbuminuria the effect of ramipril, an ACE inhibitor, on urine
albumin excretion and serum lipids. A total of 1,882 patients were screened for urine microalbumin
consecutively by dipstick test, Rapi Tex®-Albumin test and RIA. The final 28 normotensive
and microalbuminuric patients were assigned to receive either ramipril (1.25 mg/d,
n=l6) or placebo (n=l2) for 12 weeks. Throughout the study, both groups had no changes in
blood pressure, fasting plasma glucose, HbA1C, serum creatinine and electrolytes and no difference
in creatinine clearance. At week 12 only the placebo group showed the significant increment
of urine albumin excretion and triacylglycerol (30.6±38.3 to 39.0±19.7 and 167±64 to
208±77 mg/dl, respectively) but the decrement of HDL-cholesterol (46±16 to 35±6 mg/dl).
During a 3 month period, increased urine albumin excretion was observed in normotensive type
2 diabetes with microalbuminuria who received only placebo. We conclude that ramipril may
arrest the progression of albumin excretion and had favorable effects on serum lipids. Ramipril
was safe and well-tolerated without untoward side effects during the study period.
type 2 diabetics with rnicroalbuminuria the effect of ramipril, an ACE inhibitor, on urine
albumin excretion and serum lipids. A total of 1,882 patients were screened for urine microalbumin
consecutively by dipstick test, Rapi Tex®-Albumin test and RIA. The final 28 normotensive
and microalbuminuric patients were assigned to receive either ramipril (1.25 mg/d,
n=l6) or placebo (n=l2) for 12 weeks. Throughout the study, both groups had no changes in
blood pressure, fasting plasma glucose, HbA1C, serum creatinine and electrolytes and no difference
in creatinine clearance. At week 12 only the placebo group showed the significant increment
of urine albumin excretion and triacylglycerol (30.6±38.3 to 39.0±19.7 and 167±64 to
208±77 mg/dl, respectively) but the decrement of HDL-cholesterol (46±16 to 35±6 mg/dl).
During a 3 month period, increased urine albumin excretion was observed in normotensive type
2 diabetes with microalbuminuria who received only placebo. We conclude that ramipril may
arrest the progression of albumin excretion and had favorable effects on serum lipids. Ramipril
was safe and well-tolerated without untoward side effects during the study period.
Download:
PDF