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Case ReportOpen Access
Hepatocellular Adenoma: A Case Report
Sornmayura P 
,
Siripornpitak S ,
Leela-udomlipi S ,
Bunyaratvej S
,
Siripornpitak S ,
Leela-udomlipi S ,
Bunyaratvej S A case of hepatocellular adenoma (HCA) was described in a 26-year-old woman, who was a potential
kidney donor for her father and denied taking the oral contraceptive pill. A hypervascular mass of 4.1 cm in
largest dimension was detected in the liver segment V by computerized tomography and magnetic resonance
imaging (MRI). The normal levels of liver enzymes, negative serum markers for hepatitis viruses, and
non-elevated alpha- fetoprotein level were detected. The wedge resection of segment V was done with an
uneventful clinical course. In Western countries, HCAs are known to occur in women in their reproductive
periods. It may not be associated with oral contraceptive. Molecular biological studies disclosed three
variants of HCAs, i.e., I) with mutation of HNF 1-alpha gene, II) with mutation of beta-catenin gene, and III) no
mutation of the two genes. Histological correlations with the three variants as recommended by the Bordeaux
group in 2007 could not be accomplished in the present study due to overlapping histological features
between the variants I and III. The etiological factors of HCA are known to relate to the contraceptive pill
usage in female and the anabolic-androgenic-steroid administration in male. In Thailand, the occurrence of
HCA is expected to be only 0.3% of cases with hepatocellular carcinoma.
Keywords: Liver cell adenoma, Contraceptive pill, Hepatocellular carcinoma
kidney donor for her father and denied taking the oral contraceptive pill. A hypervascular mass of 4.1 cm in
largest dimension was detected in the liver segment V by computerized tomography and magnetic resonance
imaging (MRI). The normal levels of liver enzymes, negative serum markers for hepatitis viruses, and
non-elevated alpha- fetoprotein level were detected. The wedge resection of segment V was done with an
uneventful clinical course. In Western countries, HCAs are known to occur in women in their reproductive
periods. It may not be associated with oral contraceptive. Molecular biological studies disclosed three
variants of HCAs, i.e., I) with mutation of HNF 1-alpha gene, II) with mutation of beta-catenin gene, and III) no
mutation of the two genes. Histological correlations with the three variants as recommended by the Bordeaux
group in 2007 could not be accomplished in the present study due to overlapping histological features
between the variants I and III. The etiological factors of HCA are known to relate to the contraceptive pill
usage in female and the anabolic-androgenic-steroid administration in male. In Thailand, the occurrence of
HCA is expected to be only 0.3% of cases with hepatocellular carcinoma.
Keywords: Liver cell adenoma, Contraceptive pill, Hepatocellular carcinoma
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