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Case ReportOpen Access
Pentazocine-induced Fibrous Myopathy and Localized Neuropathy
Sinsawaiwong S 
,
Phanthumchinda K
,
Phanthumchinda K A 47 year-old woman who had a 4-year history of intramuscular pentazocine InJections
in the lower extremities, developed gradual stiffness and weakness of the lower extremities.
The thigh and buttock muscles were "wooden-hard" on palpation. The skin was hard, shiny and
hairless. Associated clinical and electrophysiological polyradiculopathy and multiple mononeuropathy
of the lower extremities were observed. Imaging studies showed calcification and
fibrosis of the involved muscles. Muscle biopsy revealed fibrous myopathy. Caution in longterm
usage and early recognition of pentazocine toxicity as a neuromuscular complication are important
in order to prevent irreversible drug-induced fibrous myopathy and localized neuropathy.
in the lower extremities, developed gradual stiffness and weakness of the lower extremities.
The thigh and buttock muscles were "wooden-hard" on palpation. The skin was hard, shiny and
hairless. Associated clinical and electrophysiological polyradiculopathy and multiple mononeuropathy
of the lower extremities were observed. Imaging studies showed calcification and
fibrosis of the involved muscles. Muscle biopsy revealed fibrous myopathy. Caution in longterm
usage and early recognition of pentazocine toxicity as a neuromuscular complication are important
in order to prevent irreversible drug-induced fibrous myopathy and localized neuropathy.
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