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Original ArticleOpen Access
Salivary Antiepileptic Drug Levels in Thai Children
Kankirawatana P 
A total of 123 patients were enrolled in this study. 88 patients were enrolled in the first
stage of the study, which was to evaluate the commercial salivary collecting devices: Orasure®
and Omnisol®. 35 patients were enrolled in the second stage of the study and were asked to spit
whole saliva samples for further analysis of AED levels. Serum AED levels and corresponding
saliva AED levels were paired and analyzed for the correlation coefficients with the linear regression
model. None of the commercial salivary collecting devices can provide the linear regression
correlation between the serum AED level and saliva AED level in all three AEDs studied. The correlation
coefficients of serum and whole saliva AED levels of phenobarbital, phenytoin, and carbamazepine
were highly correlated (r-squared were 0.981, 0.976, and 0.888, respectively).
Saliva samples can be used clinically to monitor the AEDs level in phenobarbital, phenytoin
and carbamazepine. This would be another alternative method of therapeutic drug monitoring
that can be done painlessly and is easier in children than the blood sampling method.
Key word : Antiepileptic Drug - Salivary Level - Thai Children
stage of the study, which was to evaluate the commercial salivary collecting devices: Orasure®
and Omnisol®. 35 patients were enrolled in the second stage of the study and were asked to spit
whole saliva samples for further analysis of AED levels. Serum AED levels and corresponding
saliva AED levels were paired and analyzed for the correlation coefficients with the linear regression
model. None of the commercial salivary collecting devices can provide the linear regression
correlation between the serum AED level and saliva AED level in all three AEDs studied. The correlation
coefficients of serum and whole saliva AED levels of phenobarbital, phenytoin, and carbamazepine
were highly correlated (r-squared were 0.981, 0.976, and 0.888, respectively).
Saliva samples can be used clinically to monitor the AEDs level in phenobarbital, phenytoin
and carbamazepine. This would be another alternative method of therapeutic drug monitoring
that can be done painlessly and is easier in children than the blood sampling method.
Key word : Antiepileptic Drug - Salivary Level - Thai Children
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