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Original ArticleOpen Access
Double-blind Study of the Efficacy of 1 Week Topical Terbinafine Cream Compared to 4 Weeks Miconazole Cream in Patients with Tinea Pedis
Leenutaphong V 
,
Niumpradit N ,
Tangwiwat S ,
Sritaveesuwan R ,
Muanprasat C
,
Niumpradit N ,
Tangwiwat S ,
Sritaveesuwan R ,
Muanprasat C Objective: To compare the efficacy of terbinafine cream for I week with the efficacy of
miconazole cream for 4 weeks in the treatment of tinea pedis.
Method: Patients who visited our clinic for tinea pedis and who had positive KOH preparation
and positive culture for dermatophyte were treated with terbinafine cream for 1 week and
placebo for 3 weeks, or with miconazole cream for 4 weeks. Evaluation was done I, 2, 3, 4 and I 0
weeks after the start of the treatment. Mycological cure was defined as presence of a positive
KOH preparation and a positive culture before treatment, and negative results for both after
treatment. Clinical efficacy was defined as mycological cure and presence of at most a total signs
and symptoms score of two.
Result: Forty-eight patients were studied. Half of them were treated with terbinafine
and placebo and the other half with miconazole. Both groups had an equal distribution as to age,
sex, race, duration and seriousness of the fungal infection and previous treatment. Mycological
cure and clinical efficacy throughout the evaluation were similar in both treatment groups. After
10 weeks, mycological cure was seen in about 52.6 per cent and 55 per cent, and clinical efficacy in
about 4 7 per cent, 45 per cent in terbinafine and miconazole treatment group respectively.
Conclusion: In the treatment of tinea pedis local application of terbinafine cream for 1
week is as good as treatment with miconazole cream for 4 weeks.
Key word : Terbinafine Cream, Miconazole, Tinea Pedis, Double-blind Study
miconazole cream for 4 weeks in the treatment of tinea pedis.
Method: Patients who visited our clinic for tinea pedis and who had positive KOH preparation
and positive culture for dermatophyte were treated with terbinafine cream for 1 week and
placebo for 3 weeks, or with miconazole cream for 4 weeks. Evaluation was done I, 2, 3, 4 and I 0
weeks after the start of the treatment. Mycological cure was defined as presence of a positive
KOH preparation and a positive culture before treatment, and negative results for both after
treatment. Clinical efficacy was defined as mycological cure and presence of at most a total signs
and symptoms score of two.
Result: Forty-eight patients were studied. Half of them were treated with terbinafine
and placebo and the other half with miconazole. Both groups had an equal distribution as to age,
sex, race, duration and seriousness of the fungal infection and previous treatment. Mycological
cure and clinical efficacy throughout the evaluation were similar in both treatment groups. After
10 weeks, mycological cure was seen in about 52.6 per cent and 55 per cent, and clinical efficacy in
about 4 7 per cent, 45 per cent in terbinafine and miconazole treatment group respectively.
Conclusion: In the treatment of tinea pedis local application of terbinafine cream for 1
week is as good as treatment with miconazole cream for 4 weeks.
Key word : Terbinafine Cream, Miconazole, Tinea Pedis, Double-blind Study
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