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Original ArticleOpen Access
Mycobacterium leprae Particle Agglutination in Diagnosis and Monitoring of Treatment of Leprosy
Kampirapap K 
IgM antibody levels against PGL-1 antigen were measured by M.leprae particle
agglutination (MLPA) in 156 untreated leprosy patients. The seropositivity rate was much higher in
newly untreated MB patients (84.7%) than in PB patients (19.7%). The mean MLPA titers in
MB and PB declined significantly after 1 month of MDT (p < 0.001). Seropositivities in
control serum specimens were 11.3 per cent in active pulmonary tuberculosis patients, 2.6 per
cent in dermatologic patients and 4.4 per cent in a healthy population, in low titers.
The study confirms that, anti PGL-1 assay using MLPA is a sensitive and specific diagnostic
tool for the diagnosis of leprosy especially MB patients. Additionally, it provides an
alternative tool in monitoring leprosy patients under MDT.
Key word : Leprosy, MLPA, Diagnosis, Monitoring
agglutination (MLPA) in 156 untreated leprosy patients. The seropositivity rate was much higher in
newly untreated MB patients (84.7%) than in PB patients (19.7%). The mean MLPA titers in
MB and PB declined significantly after 1 month of MDT (p < 0.001). Seropositivities in
control serum specimens were 11.3 per cent in active pulmonary tuberculosis patients, 2.6 per
cent in dermatologic patients and 4.4 per cent in a healthy population, in low titers.
The study confirms that, anti PGL-1 assay using MLPA is a sensitive and specific diagnostic
tool for the diagnosis of leprosy especially MB patients. Additionally, it provides an
alternative tool in monitoring leprosy patients under MDT.
Key word : Leprosy, MLPA, Diagnosis, Monitoring
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