J Med Assoc Thai 1999; 82 (10):974

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Treatment of Psoriasis Vulgaris with Topical Vitamin D Analogue (Calcipotriol): Open Multicenter Study
Kullavanijaya P Mail, Gritiyarangsan P , Huiprasert P , Leenutaphong V

Sixty one psoriasis patients, 46 males and 15 females (mean age: 40 years, range: 20-70
years) with baseline PASI score of 7.16 (± 3.66 SD) were enrolled in the study. All subjects
were advised to apply calcipotriol ointment twice daily for 6 weeks. Six patients dropped out,
five after 2 weeks and one after 4 weeks of treatment. PASI scores of fifty five patients were
reduced to 2.16 per cent, 46.78 per cent and 55.55 per cent by 2 weeks, 4 weeks and 6 weeks respectively
versus the baseline. Overall clinical assessment showed remission in 7.27 per cent
marked improvement 74.54 per cent and slight improvement 18.18 per cent. Mild erythema
were observed in fourteen patients (22.95%) that were mostly transient except for one patient.
Serum creatinine, calcium and phosphate were normal throughout the study.
Key word : Psoriasis Vulgaris, Calcipotriol, Vitamin D Analogue

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