J Med Assoc Thai 1999; 82 (11):1089

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Fetomaternal Hemorrhage After Midtrimester Genetic Amniocentesis at King Chulalongkorn Memorial Hospital
Tannirandom Y Mail, Romayanan O

Midtrimester genetic amniocentesis has become an accepted part of modern obstetric
care. Although its accuracy is well established, the risk of fetomaternal hemorrhage remains controversial.
This prospective study was conducted to determine how effective continuous ultrasound
guided amniocentesis is in preventing fetomaternal hemorrhage. The authors investigated 30
patients undergoing midtrimester genetic amniocentesis at our institution. Amniocentesis was
performed under continuous real-time ultrasound guidance using a 21-gauge, 3.5-inch long
spinal needle. Maternal serum alpha-fetoprotein (AFP) levels were determined before, at 5
minutes and at 1 hour after amniocentesis. There were no significant changes in maternal serum
AFP levels either at 5 minutes or at 1 hour after amniocentesis.
Midtrimester genetic amniocentesis performed by a trained and experienced operator
under continuous ultrasound guidance does not significantly increase the risk of fetomaternal
hemorrhage after the procedure.
Key word : Fetomaternal Hemorrhage, Amniocentesis

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