J Med Assoc Thai 1999; 82 (11):1094

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Somatic Growth and Clinical Manifestation in Formula Fed Infants Born to HIV -Infected Mothers During the First Year of Life
Gulgolgam V Mail, Ketsararat V , Niyomthai R , Junsiriyotin K , Thungjang S , Leelapom W , Tovanabutra S , Nelson K , Khamboonrueng C , Robb M

This was a comparative study of the growth and clinical manifestation between infected
and uninfected HIV infants both of whom were fed with a limited quantity of powder milk from
birth until one year of age. HIV -infected pregnant women were enrolled from the second
trimester or the beginning of the third trimester. After birth, infants had physical examinations,
body weight and height were recorded at 2, 4, 6, 9 and 12 month visits. All mothers were given 7
kilograms of infant formula at each infant visit until the infant was one year old. Diagnosis
for HIV infection in these infants was made by two positive concordant results of DNA PCR
or RNA PCR or HIV RNA. One hundred and two infants were diagnosed for HIV status and
21.5 per cent were infected. The infected infants showed signs of malnutrition. From 2-4
months of age, the averages of their weights and heights were lower than those of non-infected
infants. Abnormal clinical signs were found in most infected infants by the time they were 9-12
months old. In conclusion for the infants born to HIV- infected mothers, monitoring signs and
symptoms including their weight and height from birth till 9-12 months old, is predictive of the
infectious status of most infected infants. The administration and management of infant formula
in a limited quantity to HIV infected mothers in upper northern provinces of Thailand is possible
without causing abnormal infant growth.
Key word : Infants Born to HIV-Infected Mothers, Fomula Feeding, Growth and Clinical Manifestation, First Year of Life

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