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Original ArticleOpen Access
Efficacy of High Dose Interferon -Alpha Treatment of Chronic Hepatitis B
Techapaitoon S 
Fifteen consecutive Hepatitis B virus chronic hepatitis patients were treated with interferon
alfa-2B 10 mu tiw for 5-6 months. All patients could tolerate the side effects without
serious complications throughout the treatment period. Overall, 12 cases had normalization of
ALT (80%), 7 cases had loss of HbeAg with appearance of anti-Hbe (58.33%) and 2 cases had
loss of HbsAg with the presence of antiHBs (13.33%). The response usually associated with
improvement in histology and decrease in viral load. These results seemed to be better than
other studies with a lower dose. Further study with more patients should be done in the future.
Key word : Chronic Hepatitis B, Interferon-Alpha, Treatment
alfa-2B 10 mu tiw for 5-6 months. All patients could tolerate the side effects without
serious complications throughout the treatment period. Overall, 12 cases had normalization of
ALT (80%), 7 cases had loss of HbeAg with appearance of anti-Hbe (58.33%) and 2 cases had
loss of HbsAg with the presence of antiHBs (13.33%). The response usually associated with
improvement in histology and decrease in viral load. These results seemed to be better than
other studies with a lower dose. Further study with more patients should be done in the future.
Key word : Chronic Hepatitis B, Interferon-Alpha, Treatment
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