J Med Assoc Thai 1999; 82 (2):115

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Estradiol and Follicle-Stimulating Hormone Levels in Oophorectomized Women Applying Percutaneous 17 8-Estradiol Over the Medial Surface of the Left Arm
Taechakraichana N Mail, Udomponglukkana S , Panyakhamlerd K , Leepipatpaibul S , Limpaphayom K

To assess the changing estradiol (E2) and follicle stimulating hormone (FSH) level in
oophorectomized women applying percutaneous 17 B estradiol over the medial surface of the
left arm. Thirty-nine women, who had undergone total abdominal hysterectomy and bilateral
oophorectomy after 4 weeks, were enrolled into the study. All subjects received a daily dose
of 1.5 mg percutaneous 17 B-estradiol in 2.5 g of the gel, applied over the medial surface of the
left arm in the limited area of 150 cm2. Serum E2 and FSH were measured before and after
commencing the study at weeks 4, 8 and 12. The measurment was performed 12-14 hours after
the gel application, using time-resolved fluoroimmunoassay (FIA) method. Serum E2 significantly
increased from the baseline value at weeks 4, 8 and 12 (Median of E2 value at weeks
0, 4, 8 and 12 = 47.30, 86.78, 128.00 and 163.15 pmol/L, respectively, P

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