J Med Assoc Thai 1999; 82 (2):150

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Possible Thermogenesis with Dexfenfluramine
Roongpisuthipong C Mail, Panpakdee O , Boontawee A , Kulapongse S , Tanphaichitr V

Fifty obese patients with a body mass index greater than 25 kgfm2 were randomized into
3 groups: control (C=l9), placebo (P=18) and dexfenfluramine (D=18). A behavioral modification
program which included eating habits, exercise, attitudes, social relationships and six steps to
lifetime weight control was taught every week. All patients strictly followed the food manual
and recorded their behavior, physical activity and food intake every day through 12 weeks.
Placebo and dexfenfluramine 30 mg/day were given in a double blind placebo controlled study. The
results showed tha~ all 3 groups had significant decreases in rest times and increased activity
times (p

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