J Med Assoc Thai 1999; 82 (2):167

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The Expression of Cyclooxygenase-2 in Human Umbilical Vein Endothelial Cell Culture from Preeclampsia
Akarasereenont P Mail, Techatraisak K , Chotewuttakom S , Thawom A

We have shown that HUVEC from nonnal pregnancy contained COX-I protein but not
COX-2 protein and released 6-keto-PGF1α 277 ± 5 ng/ml (for 24 h). In contrast, HUVEC from
preeclampsia contained both COX-1 and COX-2 protein and released significantly lesser amounts
of 6-keto-PGFlα (159 ± 8 ng/ml for 24 h; p < 0.05). Thus, COX-2 is expressed in HUVEC from
preeclampsia but not in normal pregnancy and affects the release of prostacyclin suggesting the
involvement of COX-2 in the pathogenesis of preeclampsia. The development of selective inhibitors
of COX-2 may have a potential role in prevention and treatment of preeclampsia.
Key word : Preeclampsia, Cyclooxygenase-2, Human Umbilical Vein Endothelial Cell Culture

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