J Med Assoc Thai 1999; 82 (2):178

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Plasma Zinc Level and Intrauterine Growth Retardation : A Study in Pregnant Women in Ramathibodi Hospital
Roungsipragam R Mail, Borirug S , Herabutya Y

The study was designed to establish the relationship between plasma zinc level and intrauterine
growth retardation in 405 normal pregnant women with an age range from 20 to 35 years,
who attended and delivered at Ramathibodi Hospital The data were gathered from October 1994 to
April 1995. The zinc levels were obtained from blood plasma collection and the assessment of fetal
status was made after birth. Using criteria of babies with a birthweight of less than the lOth centile at
delivery. Plasma zinc level in mother was collected during antenatal care and labour. Plasma zinc
level was determined by Atomic Absorption Spectrophotometry.
The plasma zinc levels in mothers during antenatal care, labour and infant birthweight
were 66.73 µg/dl, 69.91 µg/dl and 3152.25 g respectively. Maternal plasma zinc levels during
antenatal care, labour and infant birthweight in the intrauterine growth retardation infant group
were significantly lower than that in normal growth infants (P< 0.05)
In conclusion, our study shows that measurement of maternal plasma zinc concentration
in the third trimester would highly suggest mothers at risk of delivering intrauterine growth retardation
babies. Mothers selected in this way might benefit from dietary advice and zinc supplementation
during the remaining pregnancy.
Key word : Intrauterine Growth, Plasma Zinc Level, Pregnant Women, Ramathibodi Hospital

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