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Original ArticleOpen Access
Caffeine Clearance Study in Hepatocellular Carcinoma
Tangkijvanich P 
,
Willayalertpanya S ,
Kusonsolboon T ,
Thongngam D ,
Ma!zachai V
,
Willayalertpanya S ,
Kusonsolboon T ,
Thongngam D ,
Ma!zachai V The purpose of this study was to evaluate hepatic metabolic capacity in cirrhotic patients
with hepatocellular carcinoma (HCC). We compared plasma caffeine clearance, calculated hy
two point analysis, between patients with cirrhosis alone and cirrhosis complicated with HCC.
These two groups were comparable with regards to age, sex, and the severity of liver disease.
graded by Child-Pugh score as compensated and decompensated cases. From our result, caffeine
clearance in compensated cases was clearly higher than that of decompensated cases in both
groups studied, particularly in the HCC group (p=O.OOI). The mean value of caffeine clearance in
HCC patients correlated well with the tumor staging as classified hy Okuda's criteria. There was
also a reversal correlation between tumor size and the clearance tested in compensated cases of
HCC (p=0.046), but this finding was not detected in decompensated cases (p>0.05). We conclude
that the determination of caffeine clearance can serve as a useful parameter for the asssessment of
hepatic functional reserve in cirrhotic patients complicated with HCC, and may he a useful predictor
for survival outcome.
Key word : Caffeine Clearance, Cirrhosis, Hepatocellular Carcinoma
with hepatocellular carcinoma (HCC). We compared plasma caffeine clearance, calculated hy
two point analysis, between patients with cirrhosis alone and cirrhosis complicated with HCC.
These two groups were comparable with regards to age, sex, and the severity of liver disease.
graded by Child-Pugh score as compensated and decompensated cases. From our result, caffeine
clearance in compensated cases was clearly higher than that of decompensated cases in both
groups studied, particularly in the HCC group (p=O.OOI). The mean value of caffeine clearance in
HCC patients correlated well with the tumor staging as classified hy Okuda's criteria. There was
also a reversal correlation between tumor size and the clearance tested in compensated cases of
HCC (p=0.046), but this finding was not detected in decompensated cases (p>0.05). We conclude
that the determination of caffeine clearance can serve as a useful parameter for the asssessment of
hepatic functional reserve in cirrhotic patients complicated with HCC, and may he a useful predictor
for survival outcome.
Key word : Caffeine Clearance, Cirrhosis, Hepatocellular Carcinoma
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