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Original ArticleOpen Access
The Predictive Value of Skin Thickness in the Diagnosis of Osteopenia
Limpaphayom K 
,
Panyakhamlerd K ,
Taechakraichana N ,
Kukulprasong A ,
Chaikittisilpa S
,
Panyakhamlerd K ,
Taechakraichana N ,
Kukulprasong A ,
Chaikittisilpa S Skin and bone share a similar organic constituent (type I collagen) which decreases with
time after menopause due to hypoestrogenism. The interdependence of skin and bone atrophy has
been reported(1), This study was conducted to assess the predictive value of an ultrasonographic
measurement of skin thickness in the diagnosis of osteopenia (BMD below -1.5 SD.) in peri menopausal
and early postmenopausal women. All patients had skin thickness measured by the same
radiologist and had a dual-energy X-ray absorptiometry (DEXA) scan of the lumbar spine and the
femoral neck. Of the 77 women studied, the mean age was 50.9 ± 3.0 years. Thirty patients were
in perimenopause and 47 in early postmenopause. Mean skin thickness was 2.1 ± 0.4 mm. Women
with a skin thickness of ≤ 1.7 mm carried a higher risk for developing osteopenia at the lumbar
spine (odds ratio 8.41, 95% confidence interval 2.19-32.35) and the femoral neck (odds ratio
3.88, 95% CI 1.14-13.17). Patients with a skin thickness of ≥ 2.4 mm had a lower probability of
osteopenia at the lumbar spines (odds ratio 0.17, 95% CI 0.035-0.845) and the femoral neck (odds
ratio 0.22, 95% CI 0.055-0.899). In conclusion, a low skin thickness measurement by ultrasonography
may be used as an indicator for osteopenia in perimenopausal and early postmenopausal
women.
Key word : Osteopenia, Skin Thickness, Predictive Value
time after menopause due to hypoestrogenism. The interdependence of skin and bone atrophy has
been reported(1), This study was conducted to assess the predictive value of an ultrasonographic
measurement of skin thickness in the diagnosis of osteopenia (BMD below -1.5 SD.) in peri menopausal
and early postmenopausal women. All patients had skin thickness measured by the same
radiologist and had a dual-energy X-ray absorptiometry (DEXA) scan of the lumbar spine and the
femoral neck. Of the 77 women studied, the mean age was 50.9 ± 3.0 years. Thirty patients were
in perimenopause and 47 in early postmenopause. Mean skin thickness was 2.1 ± 0.4 mm. Women
with a skin thickness of ≤ 1.7 mm carried a higher risk for developing osteopenia at the lumbar
spine (odds ratio 8.41, 95% confidence interval 2.19-32.35) and the femoral neck (odds ratio
3.88, 95% CI 1.14-13.17). Patients with a skin thickness of ≥ 2.4 mm had a lower probability of
osteopenia at the lumbar spines (odds ratio 0.17, 95% CI 0.035-0.845) and the femoral neck (odds
ratio 0.22, 95% CI 0.055-0.899). In conclusion, a low skin thickness measurement by ultrasonography
may be used as an indicator for osteopenia in perimenopausal and early postmenopausal
women.
Key word : Osteopenia, Skin Thickness, Predictive Value
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