J Med Assoc Thai 1999; 82 (7):648

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Efficacy and Safety of Twice Daily Administration of Cefpirome in the Empiric Treatment of Sepsis
Suwangool P Mail, Suttinont C , Bowonwatanuwong C , Rajanuwong A , Kulpradist S , Dusitnanond V , Chayakul P , Chetchotisakd P , Leelasupasri S , Aswapokee N

Cefpirome is a fourth-generation cephalosporin with good activity against both gram-positive
and gram-negative bacteria. A multicentre trial was performed to study the efficacy and safety
of cefpirome 2 g twice daily in the treatment of sepsis. Sixty-three cases were recruited from 10
hospitals from April 1996 to January 1998. Fifty seven cases could be evaluated according to the
protocol. The APACHE II score was used to measure severity of illness, with 46.9 per cent of
patients having APACHE II score more than 10 and two patients more than 20; both were cured.
The most common pathogens were gram-negative bacteria with E. coli predominating 16/40
( 40.0% ), followed by Klebsiella 8/40 (20.0% ). The overall clinical success rates were 54 out of 57
patients (94. 7% ). In patients with positive blood culture, the clinical cures were achieved for
20/22 (90.9%). Cefpirome showed good efficacy and safety in the empirical treatment of suspected
bacteremia or sepsis.
Key word : Cefpirome, Sepsis, Efficacy, Safety

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