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Original ArticleOpen Access
Hemodynamic Responses to Captopril During Splenectomy in Thalassemic Children
Suwanchinda V 
,
Tanphaichitr V ,
Pirayavaraporn S ,
Somprakit P ,
Laohapensang M
,
Tanphaichitr V ,
Pirayavaraporn S ,
Somprakit P ,
Laohapensang M Splenectomy in β-thalassemic children is frequently accompanied by perioperative hypertension
which occasionally is followed by convulsion. The efficacy of captopril in attenuating
the hypertensive response to splenectomy was investigated in 82 thalassemic children. The control
group, consisting of 40 patients, received intravenous furosemide (I mg/kg) preoperatively;
whereas, 42 children were randomly allocated into 2 groups to receive oral captopril (0.7 mg/kg)
or a combination of captopril (0.7 mglkg) and furosemide (1 mg/kg) before the operation.
Before anesthetic induction, both systolic and diastolic arterial pressures in the captopril
and the combined groups were significantly lower than the furosemide group (P
which occasionally is followed by convulsion. The efficacy of captopril in attenuating
the hypertensive response to splenectomy was investigated in 82 thalassemic children. The control
group, consisting of 40 patients, received intravenous furosemide (I mg/kg) preoperatively;
whereas, 42 children were randomly allocated into 2 groups to receive oral captopril (0.7 mg/kg)
or a combination of captopril (0.7 mglkg) and furosemide (1 mg/kg) before the operation.
Before anesthetic induction, both systolic and diastolic arterial pressures in the captopril
and the combined groups were significantly lower than the furosemide group (P
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