Views: 1,509 | Downloads:
21
| Responses: 0
| XML | Respond to this article | Alert & updates | Request permissions | Email to a friend |
Original ArticleOpen Access
Linear IgA Bullous Dermatosis of Childhood: A Long Term Study
Kulthanan K 
,
Akaraphanth R ,
Piamphongsant T ,
Kullavanijava P
,
Akaraphanth R ,
Piamphongsant T ,
Kullavanijava P Background: Linear IgA bullous dermatosis (LAD) of childhood is a rare acquired subepidermal
blistering disease of young children. Most of the studies were reported from the USA
and European countries.
Method: Twelve cases of Thai patients diagnosed as LAD of childhood were analyzed
concerning clinical, histopathological, immunopathological findings including treatment responses
and courses compared with those of Caucasians.
Result: The mean age of onset was 5.1 years. The areas of common involvement were the
perioral region, lower abdomen, perineum, buttock, inner thighs and extremities. Histopathology
in half of the cases showed features of dermatitis herpetiformjs or bullous pemphigoid. All patients
had positive linear lgA band at the basement membrane zone (BMZ) by direct immunofluorescence.
Only one patient had positive circulating anti BMZ antibody at the titer of I: I 0. Most patients responded
well to dapsone. The mean duration before remission was 1.9 years.
Conclusion: Our study in Thai patients with LAD of childhood produced data similar to
previous studies carried out in the Caucasian nations.
Key word : Linear lgA, Bullous Dermatosis, Childhood
blistering disease of young children. Most of the studies were reported from the USA
and European countries.
Method: Twelve cases of Thai patients diagnosed as LAD of childhood were analyzed
concerning clinical, histopathological, immunopathological findings including treatment responses
and courses compared with those of Caucasians.
Result: The mean age of onset was 5.1 years. The areas of common involvement were the
perioral region, lower abdomen, perineum, buttock, inner thighs and extremities. Histopathology
in half of the cases showed features of dermatitis herpetiformjs or bullous pemphigoid. All patients
had positive linear lgA band at the basement membrane zone (BMZ) by direct immunofluorescence.
Only one patient had positive circulating anti BMZ antibody at the titer of I: I 0. Most patients responded
well to dapsone. The mean duration before remission was 1.9 years.
Conclusion: Our study in Thai patients with LAD of childhood produced data similar to
previous studies carried out in the Caucasian nations.
Key word : Linear lgA, Bullous Dermatosis, Childhood
Download:
PDF