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Original ArticleOpen Access
The Effects of Depot Leuprorelin on IVF
Choavaratana R 
,
Suppinyopong S ,
Karavakul C ,
Nilas M
,
Suppinyopong S ,
Karavakul C ,
Nilas M The trial studied the effects of depot leuprorelin on the IVF cycle and was done on
nine couples. A single intramuscular injection of depot leuprorelin was given to the woman a
couple days before ovulation. Seven days after ovulation, the serum progesterone level was
measured and showed the same normal level as the natural ovulatory cycle. The progesterone
levels varied from 12.59 to 96.0 ng/ml. On day three of the menstruation, the hormonal profiles
showed a complete pituitary and ovarian suppression. FSH, LH and estrogen levels were less
than 4.1 mIU/ml, 2.8 mIU/ml and 9.4 pg/ml respectively. The hMG stimulation took II days on
average (9-15 days). A hundred and two oocytes were retrieved and among these there were 86
mature oocytes (84.3%). All oocytes were inseminated despite prematurity and resulted in 82.35
per cent fertilization. Normal fertilization occurred in 77.45 per cent (791102). Good embryos
developed in 58.23 per cent (46179). No more than three embryos were transferred. Four women
conceived, among them there was a set of twins. The implantation rate was 44.44 per cent (4/9).
One abortion was found in the early first trimester. The take home baby rate was 33.33 per cent
(3/9).
Key word : Depot Leuprorelin, IVF
nine couples. A single intramuscular injection of depot leuprorelin was given to the woman a
couple days before ovulation. Seven days after ovulation, the serum progesterone level was
measured and showed the same normal level as the natural ovulatory cycle. The progesterone
levels varied from 12.59 to 96.0 ng/ml. On day three of the menstruation, the hormonal profiles
showed a complete pituitary and ovarian suppression. FSH, LH and estrogen levels were less
than 4.1 mIU/ml, 2.8 mIU/ml and 9.4 pg/ml respectively. The hMG stimulation took II days on
average (9-15 days). A hundred and two oocytes were retrieved and among these there were 86
mature oocytes (84.3%). All oocytes were inseminated despite prematurity and resulted in 82.35
per cent fertilization. Normal fertilization occurred in 77.45 per cent (791102). Good embryos
developed in 58.23 per cent (46179). No more than three embryos were transferred. Four women
conceived, among them there was a set of twins. The implantation rate was 44.44 per cent (4/9).
One abortion was found in the early first trimester. The take home baby rate was 33.33 per cent
(3/9).
Key word : Depot Leuprorelin, IVF
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