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Original ArticleOpen Access
The Prevalence of Chlamydia pneumoniae Antibodies in Thai Patients with Coronary Artery Disease
Leowattana W 
,
Mahanonda N ,
Bhuripunyo K ,
Leelarasamee A ,
Pokum S ,
Suwimol B
,
Mahanonda N ,
Bhuripunyo K ,
Leelarasamee A ,
Pokum S ,
Suwimol B Blood samples were obtained from 243 consecutive coronary artery disease (CAD)
patients (177 male, 66 female) aged 35-78 years (mean, 61 years) admitted for coronary angiography
because of suspected coronary heart disease, and from 115 blood donors (91 male, 24
female) aged 25-60 years (mean, 47 years). Of the 243 CAD patients, 179 (74%) were positive by
an ELISA method for Chlamydia pneumoniae antibodies IgG and 132 (54%) were positive for C.
pneumoniae IgA. Among the 115 blood donors, 80 (70%) were positive for C. pneumoniae IgG and
49 (43%) were positive for C. pneumoniae IgA. When IgG antibodies were considered, there was
no significant difference between CAD patients and healthy controls (OR = 1.29, 95% CI =
0.79-2.10, p>0.05). In cases of positive IgA antibodies alone, there was a significant difference
between CAD patients and healthy controls (OR= 1.58, 95% CI = 1.01-2.4, p = 0.029). If both IgG
and IgA antibodies were positive, OR was increased from 1.58 to 1.80 (95% CI = 0.97-3.36, p =
0.044). In conclusion, C. pneumoniae infection is common in Thai people but chronic C. pneumoniae
infection is more common in CAD patients than in middle-aged blood donors.
Key word : Prevalence, C. Pneumoniae, CAD
patients (177 male, 66 female) aged 35-78 years (mean, 61 years) admitted for coronary angiography
because of suspected coronary heart disease, and from 115 blood donors (91 male, 24
female) aged 25-60 years (mean, 47 years). Of the 243 CAD patients, 179 (74%) were positive by
an ELISA method for Chlamydia pneumoniae antibodies IgG and 132 (54%) were positive for C.
pneumoniae IgA. Among the 115 blood donors, 80 (70%) were positive for C. pneumoniae IgG and
49 (43%) were positive for C. pneumoniae IgA. When IgG antibodies were considered, there was
no significant difference between CAD patients and healthy controls (OR = 1.29, 95% CI =
0.79-2.10, p>0.05). In cases of positive IgA antibodies alone, there was a significant difference
between CAD patients and healthy controls (OR= 1.58, 95% CI = 1.01-2.4, p = 0.029). If both IgG
and IgA antibodies were positive, OR was increased from 1.58 to 1.80 (95% CI = 0.97-3.36, p =
0.044). In conclusion, C. pneumoniae infection is common in Thai people but chronic C. pneumoniae
infection is more common in CAD patients than in middle-aged blood donors.
Key word : Prevalence, C. Pneumoniae, CAD
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