J Med Assoc Thai 1999; 82 (8):798

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The Efficacy of Chemically-Stabilized Chlorite-Matrix (TCDO*) in the Management of Late Postradiation Cystitis
Srisupundit S Mail, Kraiphibul P , Sangruchi S , Linasmita V , Chingskol K , Veerasam V

Carcinoma of the uterine cervix is the most common cancer of women in Thailand. The
most frequent complication after pelvic radiation for uterine cancer is radiation cystitis. The
management of severe late postradiation cystis is far from satisfactory. The objective of this
study was to evaluate the efficacy of chemically-stabilized chlorite-matrix (TCDO) in patients
with severe radiation cystitis. This study was conducted at the Department of Obstetrics and
Gynecology, Ramathibodi Hospital and the Department of Radiology, Siriraj Hospital between
September 1997 and September 1998. Twenty patients with grade 3 radiation cystitis after radiotherapy
were enrolled into this study. TCDO was administered at a dose of 0.5 ml/kg body weight
per day on 5 consecutive days as intravenous infusion over 4 hours. The response rate after the
first cycle was 80 per cent with 30 per cent of the patients showing complete response. The followup
time (13 patients) ranging from 1-9 months revealed no recurrent bleeding. There were no side
effects from TCDO therapy. The result suggests good efficacy of TCDO in the treatment of postradiation
Key word : Radiation Cystitis, TCDO

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